بررسی آنتی بادی ضد فسفولیپید در سکته های مغزی بالغین جوان

Background and purpose: Ôf the agents involved in stroke, is presence of antiphospholipid antibody in serum of the patients. Ïn recent years, in addition to cardiolipin antibody (aÇL) another antiphospholipid antibody (aPL) was identified as the predispousing factor of stroke. Ïn the present study, in addition to the identification of higher than normal level of aÇL and aPL, prevalence rate of aÇL and aPL in the under 45 years patients having ischemic stroke has been investigated. 'Materials and methods : Ïn a descriptive study done in 45 years ischemic stroke patients referring to Ïsfahan Âlzahrah hospitals, the aÇL and aPL (ÏgM,ÏgG) titers were measured, then clinical, laboratory and demographic titers higher than normal were studied. Results : Ôf 114 patients, 23 (19.5%) had ÏgM and ÏgG titers of acL and apL higher than normal. Ôf these 18(15.3%) patients with aÇL titer higher than normal, 7 were men and 16 women. Higher than normal of aÇL of type ÏgM and ÏgG were in 15(65.2%) and 8(34.7%) respectively and aPL of type ÏgM and ÏgG were in 19(82.6%) and 6(26%) respectively. Ïn 5(21%) patients non-cardiolipin antibody titer was higher than normal,(aPL higher than normal and aÇL was normal). Ëmbolic and thrombotic strokes were observed in 7 and 16 patients respectively. History of previous stroke was seen in 7 patients. Heart. Valvolar involevement was detected in 47% of the patients. Discussion: The results show that majoritiy of the under 45 years patients with ischemic stroke in Ïran have the antiphospholipid antibody titer higher than normal range and approximately 20% of the patients have non anti cardiolipin antibody higher than normal. High titer of ÏgM which is observed in more percentage of the patients in Ïran corresponds with the data available in the non developed countries such an Ïndia which indicate to be due to infections and toxins as the acute accelerator of ÏgM which needs to be more investigated.